Peripheral blood minimal residual disease may replace bone marrow minimal residual disease as an immunophenotypic biomarker for impending relapse in acute myeloid leukemia
| Autor: | Yvonne J M Oussoren-Brockhoff, W Zeijlemaker, Alexander N Snel, Gert J. Ossenkoppele, Willemijn J Scholten, D Veldhuizen, Gerrit-Jan Schuurhuis, Jacqueline Cloos, Angèle Kelder |
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| Přispěvatelé: | Hematology laboratory, CCA - Biomarkers, Hematology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Neoplasm Residual CD34 Antineoplastic Agents Gastroenterology Immunophenotyping 03 medical and health sciences 0302 clinical medicine Antigens CD Bone Marrow Recurrence hemic and lymphatic diseases Internal medicine Humans Medicine Cumulative incidence Survival analysis Aged business.industry Myeloid leukemia Hematology Middle Aged Prognosis Survival Analysis Minimal residual disease Consolidation Chemotherapy body regions Leukemia Myeloid Acute medicine.anatomical_structure Oncology Case-Control Studies 030220 oncology & carcinogenesis Leukocytes Mononuclear Biomarker (medicine) Female Bone marrow business Biomarkers 030215 immunology |
| Zdroj: | Zeijlemaker, W, Kelder, A, Oussoren-Brockhoff, Y J M, Scholten, W, Snel, A N, Veldhuizen, D, Cloos, J, Ossenkoppele, G J & Schuurhuis, G J 2016, ' Peripheral blood minimal residual disease may replace bone marrow minimal residual disease as an immunophenotypic biomarker for impending relapse in acute myeloid leukemia ', Leukemia, vol. 30, no. 3, pp. 708-715 . https://doi.org/10.1038/leu.2015.255 Leukemia, 30(3), 708-715. Nature Publishing Group |
| ISSN: | 0887-6924 |
| DOI: | 10.1038/leu.2015.255 |
| Popis: | As relapses are common in acute myeloid leukemia (AML), early relapse prediction is of high importance. Although conventional minimal residual disease (MRD) measurement is carried out in bone marrow (BM), peripheral blood (PB) would be an advantageous alternative source. This study aims to investigate the specificity of leukemia-associated immunophenotypes used for MRD detection in blood samples. Consistency of PB MRD as compared with BM MRD was determined in flow cytometric data of 205 paired BM and PB samples of 114 AML patients. A significant correlation was found between PB and BM MRD (r=0.67, P |
| Databáze: | OpenAIRE |
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