Extrahepatic manifestations of hepatitis E virus: An overview
| Autor: | Ioannis V Mitselos, Fotios S Fousekis, Dimitrios K. Christodoulou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
kidney
Myocarditis viruses Myelitis Review hematologic diseases Glucosephosphate Dehydrogenase Guillain-Barre Syndrome medicine.disease_cause 03 medical and health sciences neurologic manifestations 0302 clinical medicine Hepatitis E virus Membranoproliferative glomerulonephritis medicine Humans hepatitis e lcsh:RC799-869 Molecular Biology Hepatology business.industry virus diseases medicine.disease Hepatitis E Cryoglobulinemia digestive system diseases Pancreatitis 030220 oncology & carcinogenesis Immunology Kidney Diseases lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Nervous System Diseases Autoimmune hemolytic anemia business Encephalitis |
| Zdroj: | Clinical and Molecular Hepatology, Vol 26, Iss 1, Pp 16-23 (2020) Clinical and Molecular Hepatology |
| ISSN: | 2287-285X 2287-2728 |
| Popis: | Hepatitis E virus (HEV) is a significant health problem with approximately 20 million individuals infected annually. HEV infection has been associated with a wide spectrum of extrahepatic manifestations, including neurological, hematological and renal disorders. Guillain-Barré syndrome and neuralgic amyotrophy are the most frequent neurological manifestations. In addition, HEV infection has been observed with other neurological diseases, such as encephalitis, myelitis and Bell’s palsy. Hematologic manifestations include anemia due to glucose-6-phospate dehydrogonase deficiency, autoimmune hemolytic anemia and severe thrombocytopenia. Membranoproliferative glomerulonephritis and relapse IgA nephropathy with or without coexisting cryoglobulinemia appear to be the most common renal injuries related with HEV infection. Also, HEV infection has been associated with acute pancreatitis and other immune-mediated manifestations, such as arthritis and myocarditis. However, the pathophysiologic mechanisms of HEV-related extrahepatic manifestations are still largely unclear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|