Certain risk factors for patients with desmoid tumors warrant reconsideration of local therapy strategies
| Autor: | Valerae O. Lewis, Alexander J. Lazar, Bryan S. Moon, Maria Alejandra Zarzour, Christina L. Roland, Ravin Ratan, Andrew J. Bishop, B. Ashleigh Guadagnolo, Barry W. Feig, Wei Lien Wang, Keila E. Torres, Jace P. Landry |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Treatment outcome Systemic therapy Gastroenterology Article Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Interquartile range Internal medicine medicine Humans Combined Modality Therapy 030212 general & internal medicine Child Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Infant Torso Extremities Middle Aged Texas Survival Rate Radiation therapy Fibromatosis Aggressive Cross-Sectional Studies Treatment Outcome Oncology Head and Neck Neoplasms Child Preschool 030220 oncology & carcinogenesis Female Active treatment Neoplasm Recurrence Local business Follow-Up Studies Cohort study |
| Zdroj: | Cancer |
| ISSN: | 1097-0142 0008-543X |
| Popis: | OBJECTIVE: To evaluate treatment outcomes in patients with desmoid tumors (DT) receiving local therapy with surgery alone, radiation therapy (RT) alone, or combined modality RT and surgery (CMT). METHODS: We performed a cross-sectional cohort study of 412 patients with non-mesenteric DTs who received local therapy at our institution between 1965 and 2018. RESULTS: Median follow-up time was 95 months (range, 1–509). Local recurrence occurred in 127 patients (31%) at a median time of 21 months (range, 3–295). The 5-year LC was 67%. Patient or tumor factors that were significantly associated with poorer 5-year LC on multivariable analysis included: age ≤30 years (57% vs. 75% > 30; HR 1.73, P=0.004), extremity location (57% vs. 71% non-extremity; HR 1.77, P=0.004), and large tumors (>10cm: 59%; HR 2.17, P=0.004; 5–10cm: 65%; HR 1.71, P=0.02; vs ≤5cm 76%). Subset analyses of these high risk patients revealed no local therapy strategy as superior for young patients ≤30 years (surgery P=0.33, HR 1.42; RT P=0.38, HR 1.36) or for large tumors >10cm (surgery P=0.46, HR 1.55; RT P=0.91, HR 0.91). However, for patients with extremity tumors, surgery alone was significantly associated with inferior LC (surgery P |
| Databáze: | OpenAIRE |
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