Association of COL1A2 (PvuII) gene polymorphism with risk and severity of dental fluorosis – A case control study
| Autor: | C. Rahila, J. John Kirubaharan, A. Sujatha, MB Aswath Narayanan, SG Ramesh Kumar, A. Leena Selvamary |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Population lcsh:Medicine COL1A2 gene Logistic regression 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine stomatognathic system Polymorphism (computer science) Internal medicine Medicine education General Dentistry education.field_of_study business.industry lcsh:R Gene polymorphisms Case-control study 030206 dentistry Odds ratio medicine.disease lcsh:RK1-715 Dental fluorosis stomatognathic diseases lcsh:Dentistry Original Article Gene polymorphism business |
| Zdroj: | The Saudi Dental Journal Saudi Dental Journal, Vol 31, Iss 4, Pp 463-468 (2019) |
| ISSN: | 1013-9052 |
| Popis: | Introduction: Dental fluorosis is a foremost public health problem in many countries, including India. Very few studies investigated gene polymorphism and risk of dental fluorosis. Genetic polymorphisms in Collagen Type I, alpha 2 (COL1A2) gene, found to be linked with bone pathogenesis, may affect the tooth formation resulting in the vulnerability to dental fluorosis. Aim: To assess the association between COL1A2 (PvuII) gene polymorphism and risk as well as severity of dental fluorosis. Methods: The present case control study was conducted among participants with (n = 60) and without (n = 60) dental fluorosis. Dental fluorosis was assessed using Modified Dean’s fluorosis index (1942). The PvuII polymorphisms (in exon 25) inside the COL1A2 gene were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) procedure. Statistical analysis were carried out with Chi-square test and Odds Ratio (OR) was determined with multivariate logistic regression analysis. Results: The genetic polymorphism in COL1A2 PvuII was found to be associated with the risk of dental fluorosis which was highly significant (p |
| Databáze: | OpenAIRE |
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