Strong YB-1 Expression Predicts Liver Recurrence Following Resection for Colorectal Metastases
| Autor: | Ivo Giovannini, Francesco Majellaro, Fabio Maria Vecchio, Gennaro Nuzzo, Vincenzo Arena, Francesco Ardito, Gennaro Grande, Maria Vellone, Felice Giuliante, Ilaria Pennacchia |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Settore MED/18 - CHIRURGIA GENERALE Kaplan-Meier Estimate YB-1 Disease-Free Survival Resection Cohort Studies Text mining Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Hepatectomy Humans Risk factor Survival rate Aged Retrospective Studies Aged 80 and over Liver resection business.industry Liver Neoplasms Gastroenterology Molecular markers Middle Aged Prognosis Immunohistochemistry Survival Analysis Tumor recurrence Colorectal liver metastases Liver recurrence Logistic Models Treatment Outcome Multivariate Analysis Cancer cell Female Surgery Y-Box-Binding Protein 1 Neoplasm Recurrence Local Colorectal Neoplasms business |
| Zdroj: | Journal of gastrointestinal surgery 18 (2014): 1987–93. doi:10.1007/s11605-014-2657-3 info:cnr-pdr/source/autori:Ardito, Francesco; Arena, Vincenzo; Vellone, Maria; Grande, Gennaro; Pennacchia, Ilaria; Majellaro, Francesco; Giovannini, Ivo; Vecchio, Fabio M; Nuzzo, Gennaro; Giuliante, Felice/titolo:Strong YB-1 Expression Predicts Liver Recurrence Following Resection for Colorectal Metastases./doi:10.1007%2Fs11605-014-2657-3/rivista:Journal of gastrointestinal surgery/anno:2014/pagina_da:1987/pagina_a:93/intervallo_pagine:1987–93/volume:18 |
| ISSN: | 1873-4626 1091-255X |
| Popis: | The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection. Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity). YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5 % (p = 0.023). Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p = 0.034). These results were not influenced by clinical prognostic factors of tumor recurrence. This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection. |
| Databáze: | OpenAIRE |
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