rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial

Autor: Norman W. Barton, Ajit Mahaveer, Luca A. Ramenghi, Ingrid Hansen-Pupp, Faizah Bhatti, Jason Higginson, Emily Jochim, Alexandra Mangili, Boubou Hallberg, Carlo Dani, Mirjam M. van Weissenbruch, David Ley, Peter Reynolds, Jou Ku Chung, Olachi J. Mezu-Ndubuisi, Lois E.H. Smith, Mark A. Turner, Ann Hellström, Kathryn Beardsall, Neil Marlow, Mohamed Hamdani, Adina Tocoian, Carmen Giannantonio, David B. Dunger
Přispěvatelé: Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, NCA - Neurobiology of mental health, Amsterdam Reproduction & Development (AR&D)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Pediatrics
Severity of Illness Index
law.invention
0302 clinical medicine
Randomized controlled trial
law
Phase (matter)
Medicine
030212 general & internal medicine
Insulin-Like Growth Factor I
Infusions
Intravenous
bronchopulmonary dysplasia
intraventricular hemorrhage
neonatology
retinopathy of prematurity
Bronchopulmonary Dysplasia
Cerebral Hemorrhage
Female
Gestational Age
Humans
Infant
Extremely Premature
Infant
Newborn
Infant
Premature
Insulin-Like Growth Factor Binding Protein 3
Recombinant Proteins
Retinopathy of Prematurity
Treatment Outcome
Gestational age
Retinopathy of prematurity
3. Good health
Intraventricular hemorrhage
030220 oncology & carcinogenesis
Anesthesia
030211 gastroenterology & hepatology
Intravenous
medicine.medical_specialty
Infusions
Extremely Premature
Article
03 medical and health sciences
030225 pediatrics
Severity of illness
Neonatology
Premature
business.industry
Postmenstrual Age
Infant
medicine.disease
Newborn
Bronchopulmonary dysplasia
Pediatrics
Perinatology and Child Health
business
Zdroj: The Journal of pediatrics
Ley, D, Hallberg, B, Hansen-Pupp, I, Dani, C, Ramenghi, L A, Marlow, N, Beardsall, K, Bhatti, F, Dunger, D, Higginson, J D, Mahaveer, A, Mezu-Ndubuisi, O J, Reynolds, P, Giannantonio, C, van Weissenbruch, M, Barton, N, Tocoian, A, Hamdani, M, Jochim, E, Mangili, A, Chung, J-K, Turner, M A, Smith, L E H & Hellström, A 2019, ' rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial ', Journal of Pediatrics, vol. 206, pp. 56-65.e8 . https://doi.org/10.1016/j.jpeds.2018.10.033
Journal of Pediatrics, 206, 56-65.e8. Mosby Inc.
ISSN: 1097-6833
0022-3476
DOI: 10.1016/j.jpeds.2018.10.033
Popis: Objective: To investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy of prematurity (ROP) and other complications of prematurity among extremely preterm infants. Study design: This phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age of 230/7 weeks to 276/7 weeks were randomly allocated to rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion from
Databáze: OpenAIRE
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