Secondary Philadelphia chromosome and erythrophagocytosis in a relapsed acute myeloid leukemia after hematopoietic cell transplantation
| Autor: | Christopher R. Conley, Katalin Kelemen, Komal Galani, Patricia T. Greipp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Erythrocytes Transplantation Conditioning medicine.medical_treatment Fusion Proteins bcr-abl Chromosomal translocation Hematopoietic stem cell transplantation Biology Philadelphia chromosome Article Myeloid Neoplasm Phagocytosis hemic and lymphatic diseases Genetics medicine Humans Philadelphia Chromosome Molecular Biology In Situ Hybridization Fluorescence Aged Chemotherapy Hematopoietic Stem Cell Transplantation Myeloid leukemia medicine.disease Erythrophagocytosis Transplantation Leukemia Myeloid Acute Cytogenetic Analysis Cancer research Female Neoplasm Recurrence Local |
| Popis: | The acquisition of Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation (HCT). A secondary Ph at relapse is of clinical importance because it provides a therapeutic target for tyrosine kinase inhibitors along with or in replacement of chemotherapy. We describe a case of relapsed acute myeloid leukemia after HCT that developed a BCR/ABL-1 translocation along with erythrophagocytosis by blasts as a secondary change at the time of relapse. The progression of this patient's myeloid neoplasm from myelodysplastic syndrome to acute myeloid leukemia and relapsed AML after HCT was accompanied by a stepwise cytogenetic evolution: a deletion 20q abnormality subsequently acquired deletion 7q and, finally, at relapse after HCT, a secondary Ph was gained. The relationship between the secondary Ph and the erythrophagocytosis by blasts is not clear. We review the possible pathogenesis and cytogenetic associations of erythrophagocytosis by blasts, a rare feature in acute leukemias. |
| Databáze: | OpenAIRE |
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