A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention
| Autor: | Jonathan Herskovitz, Srijanee Das, Ashish Baldi, Suvarthi Das, Caroline G. Saksena, Jatin Machhi, Tapan A Patel, Mahmudul Hasan, Lalitkumar K. Vora, Preet Amol Singh, Farah Shahjin, David Oupicky, Milankumar Patel, Pravin Yeapuri, Kenneth S. Hettie, Raj Kumar, Jacob D. Cohen, Dhruvkumar Soni, Linda Chang, Maxim D. Oleynikov, Bhavesh D. Kevadiya, Howard E. Gendelman, Neha Bajwa, Ryan F. Donnelly, Insiya Mukadam, Mai Mohamed Abdelmoaty, Rajashree Chakraborty |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Immunology Neuroscience (miscellaneous) Mesenchymal stem cells (MSCs) Cellular homeostasis Biology Antiviral Agents 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Immune system Drug Delivery Systems medicine Extracellular Immunology and Allergy Animals Humans Immunologic Factors Antigen-presenting cell Pharmacology Immunity Cellular Invited Review SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mesenchymal stem cell COVID-19 Microvesicles Cell biology COVID-19 Drug Treatment Coronavirus disease 2019 (COVID-19) 030104 developmental biology medicine.anatomical_structure Drug delivery Extracellular vesicles (EVs) 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmune Pharmacology |
| ISSN: | 1557-1904 |
| Popis: | Graphical Abstract Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease. Interest in EVs as putative vaccines or drug delivery vehicles are substantial. The vesicles have properties of receptors nanoassembly on their surface. EVs can interact with specific immunocytes that include antigen presenting cells (dendritic cells and other mononuclear phagocytes) to elicit immune responses or affect tissue and cellular homeostasis or disease. Due to potential advantages like biocompatibility, biodegradation and efficient immune activation, EVs have gained attraction for the development of treatment or a vaccine system against the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. In this review efforts to use EVs to contain SARS CoV-2 and affect the current viral pandemic are discussed. An emphasis is made on mesenchymal stem cell derived EVs’ as a vaccine candidate delivery system. |
| Databáze: | OpenAIRE |
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