Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model
| Autor: | Luyong Zhang, Meyada Khaled, Ghania Belaaloui, Zhenzhou Jiang, Xiong Zhu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment Mice Nude Breast Neoplasms Docetaxel Pharmacology complex mixtures 030226 pharmacology & pharmacy BALB/c 03 medical and health sciences Mice 0302 clinical medicine Breast cancer In vivo Cell Line Tumor otorhinolaryngologic diseases medicine Animals Humans Pharmacology (medical) Etoposide Podophyllotoxin Chemotherapy Mice Inbred BALB C biology business.industry beta-Cyclodextrins Cancer medicine.disease biology.organism_classification Antineoplastic Agents Phytogenic Xenograft Model Antitumor Assays 2-Hydroxypropyl-beta-cyclodextrin Infectious Diseases 030220 oncology & carcinogenesis Immunology Administration Intravenous Female Taxoids business medicine.drug Drugs Chinese Herbal |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 22(10) |
| ISSN: | 1437-7780 |
| Popis: | Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely related to the lignan podophyllotoxin, was found to be a potent antitumor and antiproliferative agent, in several tumor cells, in vitro. However, DPT has not been used clinically yet because of the lack of in vivo studies. This study is the first report demonstrating the antitumor effect of DPT on MDA-MB-231 human breast cancer xenografts in nude mice. DPT, significantly, inhibited the growth of MDA-MB-231 xenograft in BALB/c nude mice. The T/C value (the value of the relative tumor volume of treatment group compared to the control group) of groups treated with 5, 10, and 20 mg/kg of intravenous DPT-HP-β-CD was 42.87%, 34.04% and 9.63%, respectively, suggesting the positive antitumor activity of DPT. In addition, the antitumor effect of DPT-HP-β-CD (20 mg/kg) in human breast cancer MDA-MB-231 xenograft was more effective than etoposide (VP-16) (20 mg/kg) and docetaxel (20 mg/kg). These findings suggest that this drug is a promising chemotherapy candidate against human breast carcinoma. |
| Databáze: | OpenAIRE |
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