Cloning of a Novel Epidermal Growth Factor Repeat Containing Gene EGFL6: Expressed in Tumor and Fetal Tissues
| Autor: | Julio J. Mulero, Richard P. Berntsen, John E. Ford, Deborah B. Loeb, Radoje T. Drmanac, George Yeung |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Repetitive Sequences Amino Acid Signal peptide Molecular Sequence Data Integrin Fetus Epidermal growth factor Neoplasms Gene expression Genetics Humans Amino Acid Sequence Cloning Molecular Peptide sequence Gene Gene Library Glycoproteins chemistry.chemical_classification Regulation of gene expression Membrane Glycoproteins Base Sequence Epidermal Growth Factor biology Calcium-Binding Proteins Gene Expression Regulation Developmental Nucleic Acid Hybridization Middle Aged Molecular biology Neoplasm Proteins Gene Expression Regulation Neoplastic chemistry Organ Specificity Multigene Family biology.protein Female Peptides Glycoprotein Cell Adhesion Molecules |
| Zdroj: | Genomics. 62:304-307 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.1999.6011 |
| Popis: | The epidermal growth factor (EGF) repeat superfamily of genes often encodes proteins that govern cellular proliferative responses. Using a high-throughput screening by hybridization approach, a novel human EGF repeat superfamily member that maps to human chromosome X was identified. Termed EGFL6, the gene encodes a predicted signal peptide, suggesting that it is secreted. Other predicted features include four and one-half EGF-like repeat domains, two N-linked glycosylation sites, an integrin association motif (RGD), and a tyrosine phosphorylation site. Importantly, its transcripts are expressed in brain and lung tumor and fetal tissues, but are generally absent from normal adult tissues. Implications with respect to cell cycle regulation and oncogenesis are discussed. |
| Databáze: | OpenAIRE |
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