Pentraxin 3 (PTX3) Is Associated with Severe Sepsis and Fatal Disease in Emergency Room Patients with Suspected Infection: A Prospective Cohort Study
| Autor: | Tero Vahlberg, Janne Aittoniemi, Reetta Huttunen, Raija Uusitalo-Seppälä, Pertti Koskinen, Aila Leino, Esa Rintala |
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| Přispěvatelé: | Lääketieteen yksikkö - School of Medicine, University of Tampere |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Bacterial Diseases
Male Critical Care and Emergency Medicine Epidemiology Cohort Studies Patient Admission Pathology Prospective Studies Prospective cohort study Aged 80 and over Multidisciplinary biology PTX3 Middle Aged Prognosis Serum Amyloid P-Component Infectious Diseases C-Reactive Protein Medicine Regression Analysis Female Emergency Service Hospital Cohort study Research Article Adult Calcitonin medicine.medical_specialty Adolescent Biolääketieteet - Biomedicine Science Sepsis Young Adult Pharmacotherapy Diagnostic Medicine Internal medicine medicine Humans Protein Precursors Intensive care medicine Aged business.industry C-reactive protein Emergency department ta3121 medicine.disease Systemic inflammatory response syndrome ROC Curve Multivariate Analysis biology.protein business Biomarkers General Pathology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e53661 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Background Early diagnostic and prognostic stratification of patients with suspected infection is a difficult clinical challenge. We studied plasma pentraxin 3 (PTX3) upon admission to the emergency department in patients with suspected infection. Methods The study comprised 537 emergency room patients with suspected infection: 59 with no systemic inflammatory response syndrome (SIRS) and without bacterial infection (group 1), 67 with bacterial infection without SIRS (group 2), 54 with SIRS without bacterial infection (group 3), 308 with sepsis (SIRS and bacterial infection) without organ failure (group 4) and 49 with severe sepsis (group 5). Plasma PTX3 was measured on admission using a commercial solid-phase enzyme-linked immunosorbent assay (ELISA). Results The median PTX3 levels in groups 1–5 were 2.6 ng/ml, 4.4 ng/ml, 5.0 ng/ml, 6.1 ng/ml and 16.7 ng/ml, respectively (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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