A biokinetic and dosimetric model for ionic indium in humans
| Autor: | Sören Mattsson, Martin Andersson, Lennart Johansson, Sigrid Leide-Svegborn |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
inorganic chemicals Metabolic Clearance Rate chemistry.chemical_element Radiation Dosage Models Biological Effective dose (radiation) 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Animal data 0302 clinical medicine Metabolic clearance rate Humans Tissue Distribution Radiology Nuclear Medicine and imaging Tissue distribution Radiological and Ultrasound Technology Phantoms Imaging business.industry Indium Radioisotopes digestive oral and skin physiology Radiochemistry respiratory system Kinetics chemistry Organ Specificity 030220 oncology & carcinogenesis Indium chloride Radiopharmaceuticals Indium arsenide Nuclear medicine business Indium circulatory and respiratory physiology |
| Zdroj: | Physics in Medicine & Biology. 62:6397-6407 |
| ISSN: | 1361-6560 |
| Popis: | This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for 111In- and 113mIn-ions. The proposed biokinetic model is compared with previously published biokinetic indium models published by the ICRP. The absorbed doses are calculated using the ICRP/ICRU adult reference phantoms and the effective dose is estimated according to ICRP Publication 103. The effective doses for 111In and 113mIn are 0.25 mSv MBq-1 and 0.013 mSv MBq-1 respectively. The updated biokinetic and dosimetric models presented in this paper take into account human data and new animal data, which represent more detailed and presumably more accurate dosimetric data than that underlying previous models for indium. |
| Databáze: | OpenAIRE |
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