Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy
| Autor: | Ruyi Lin, Ni Li, Yasuhiko Tabata, Jian-Qing Gao, Qiong Bian, Tian-Yuan Zhang, Honghui Wu, Yuanqin Su, Xinchi Jiang, Ting Huang, Jinqiang Wang, Daishun Ling, Hongcui Cao, Ai Li, Zhen Gu |
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| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Multidisciplinary Coronavirus disease 2019 (COVID-19) Chemistry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Materials Science SciAdv r-articles Life Sciences Bioengineering Mitochondrion Cell biology chemistry.chemical_compound Biomedicine and Life Sciences Intracellular Iron oxide nanoparticles Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Description Iron oxide nanoparticles could significantly promote the mitochondrial transfer from mesenchymal stem cells to the injured cells. The transfer of mitochondria between cells has recently been revealed as a spontaneous way to protect the injured cells. However, the utilization of this natural transfer process for disease treatment is so far limited by its unsatisfactory transfer efficiency and selectivity. Here, we demonstrate that iron oxide nanoparticles (IONPs) can augment the intercellular mitochondrial transfer from human mesenchymal stem cells (hMSCs) selectively to diseased cells, owing to the enhanced formation of connexin 43–containing gap junctional channels triggered by ionized IONPs. In a mouse model of pulmonary fibrosis, the IONP-engineered hMSCs achieve a remarkable mitigation of fibrotic progression because of the promoted intercellular mitochondrial transfer, with no serious safety issues identified. The present study reports a potential method of using IONPs to enable hMSCs for efficient and safe transfer of mitochondria to diseased cells to restore mitochondrial bioenergetics. |
| Databáze: | OpenAIRE |
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