Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

Autor:	Gene S. Tan, Florian Krammer, Peter Palese, Megan E. Ermler, Chi-Jene Chen, Rong Hai
Přispěvatelé:	Dermody, TS
Rok vydání:	2015
Předmět:	0301 basic medicine Hemagglutinin Glycoproteins Influenza Virus endocrine system Growth kinetics viruses Immunology education Gene Expression Hemagglutinin Glycoproteins Influenza Virus Viral Plaque Assay Biology Virus Replication Medical and Health Sciences Microbiology Epitope Genomic Instability Cell Line Vaccine Related 03 medical and health sciences Epitopes Neutralization Tests Biodefense Virology parasitic diseases Vaccines and Antiviral Agents Humans Agricultural and Veterinary Sciences Prevention Influenza a Biological Sciences Influenza Recombinant Proteins Emerging Infectious Diseases Infectious Diseases 030104 developmental biology Stalk Influenza A virus Influenza Vaccines Insect Science Pneumonia & Influenza biology.protein Antibody Infection
Zdroj:	Journal of virology, vol 90, iss 7
ISSN:	1098-5514
Popis:	A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946580eda372e03813a66e1e796d831 https://pubmed.ncbi.nlm.nih.gov/26764009 Zobrazit plný text záznamu