Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?
| Autor: | Larisa M. Haupt, Konstantin I. Momot, Honor J. Hugo, Erik W. Thompson, Xuan Huang, Jason J. Northey, Gina Reye, Ryan J Murphy |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Carcinogenesis Breast Neoplasms medicine.disease_cause Fibrous stroma Mechanical pressure Breast cancer medicine Pressure Humans Breast Mechanical stiffness Mammographic density Positive feedback Breast Density Review Paper biology MAMMOGRAPHIC DENSITY medicine.disease Cell biology Biomechanical Phenomena Extracellular Matrix Oncology Proteoglycan biology.protein Proteoglycans Female Collagen Tissue stiffness Biomarkers Mammography |
| Zdroj: | Journal of Mammary Gland Biology and Neoplasia |
| ISSN: | 1573-7039 1083-3021 |
| Popis: | Regions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and other biological settings, of a positive feedback cycle of force promoting PG synthesis, such as in articular cartilage, due to increased pressure on weight bearing joints. Furthermore, we present evidence to suggest a pro-tumorigenic effect of increased mechanical force on epithelial cells in contexts where PG-mediated, aligned collagen fibrous tissue abounds, with implications for breast cancer development attributable to high MD. Finally, we summarise means through which this positive feedback mechanism of PG synthesis may be intercepted to reduce mechanical force within tissues and thus reduce disease burden. |
| Databáze: | OpenAIRE |
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