Maternal nutrient intake and fetal gastroschisis: A case-control study
| Autor: | Marco Aurelio Knippel Galletta, Rossana Pulcineli Vieira Francisco, Maria de Lourdes Brizot, Ana Maria da Silva Sousa, Sonia Tucunduva Phillippi, Rui Curi, Agatha Sacramento Rodrigues, Sandra F Centofanti |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Gestational Age 030105 genetics & heredity 03 medical and health sciences chemistry.chemical_compound Young Adult Fetus Pregnancy Genetics medicine Odds Ratio Humans Micronutrients Genetics (clinical) Gastroschisis Methionine Obstetrics business.industry Abdominal wall defect Case-control study Gestational age Nutrients medicine.disease Fetal Diseases 030104 developmental biology chemistry Maternal Exposure Case-Control Studies Female business Energy Intake Body mass index |
| Zdroj: | American journal of medical genetics. Part A. 179(8) |
| ISSN: | 1552-4833 |
| Popis: | Fetal gastroschisis is a paraumbilical abdominal wall defect with herniation of the abdominal organs. This multifactorial malformation occurs in young pregnant women, and the underlying cause of the disease remains unknown; however, nutritional factors may play a role in its development. This case-control study explored the association of maternal nutrient intake with the occurrence of gastroschisis. The gastroschisis group (GG) comprised 57 pregnant women with fetuses with gastroschisis, and the control group (CG) comprised 114 pregnant women with normal fetuses matched for maternal age, gestational age, and preconception body mass index classification. Nutritional assessments related to the preconception period were obtained using the food consumption frequency questionnaire, and nutrient intakes were calculated using nutrition programs. The median daily calorie intake was higher (2,382.43 vs. 2,198.81; p = .041) in the GG than in the CG. The median intake of methionine (763.89 vs. 906.34; p = .036) and threonine (1,248.34 vs. 1,437.01; p = .018) was lower in the GG than in the CG. Pregnant women with fetuses with gastroschisis have a diet characterized by higher calorie intake and lower levels of essential amino acids (methionine and threonine) during the preconception period than pregnant women with normal fetuses. |
| Databáze: | OpenAIRE |
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