Molecular epidemiological investigation of Mayaro virus in febrile patients from Goiania City, 2017-2018
| Autor: | Filipe Romero Rebello Moreira, Isabele Pereira Tannous, Marco Tulio Antonio García-Zapata, Renato S. Aguiar, Elisângela de Paula Silveira-Lacerda, Elisângela Gomes da Silva, Hugo Delleon Silva, Carlos Eduardo Anunciação, Mariane Talon de Menezes, Adriano Roberto Vieira de Sousa, Gabrielly R. Abrantes, Alice Laschuk Herlinger, Giovanni Rezza, Marina Machado dos Santos, Amilcar Tanuri, Juliana Pires Ribeiro, Rodrigo Brindeiro, Natália Santana do Nascimento, Sandra Brunini, Clever Gomes Cardoso, Richard Araújo Maia, Kauana Ferreira Arruda, Orlando C. Ferreira, Jordana Faria Corrêa, Rafael Moura Barbosa |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Fever viruses 030106 microbiology Alphavirus Dengue virus Biology medicine.disease_cause Microbiology Virus Dengue fever 03 medical and health sciences Young Adult Genotype Epidemiology Genetics medicine Prevalence Humans Molecular Biology Ecology Evolution Behavior and Systematics Aged Molecular Epidemiology Transmission (medicine) Alphavirus Infections Incidence virus diseases Outbreak biochemical phenomena metabolism and nutrition Middle Aged medicine.disease Rash Virology 030104 developmental biology Infectious Diseases Female medicine.symptom Brazil |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 95 |
| ISSN: | 1567-7257 |
| Popis: | Mayaro virus (MAYV) has historically been associated with sylvatic transmission; however, urban outbreaks have been reported in Brazil, including cases of co-detection with dengue virus (DENV). Therefore, we performed a molecular survey to investigate MAYV circulation and cocirculation with DENV within Goiania, a major city in Central-West Brazil. Among 375 subjects with arbovirus-like symptoms, 259 were positive for DENV and 26 for MAYV. Of these, 17 were coinfected with DENV-2, suggesting co-transmission of the viruses. The most common complaints at the time of inclusion were myalgia, headache, fever, arthralgia, retro-orbital pain, and skin rash. No specific symptoms were associated with MAYV when either detected alone or co-detected with DENV, compared to that when DENV was detected alone. Most MAYV-infected subjects were women with no recent travel history to rural/sylvatic areas. Phylogenetic reconstruction indicated that the MAYV identified in this study is closely related with a lineage observed in Peru, belonging to genotype D. Our results corroborate the growing circulation of MAYV in urban environments in Brazil and reinforce the need to implement laboratory diagnosis in the Unified Health System, considering that the clinical manifestations of Mayaro fever are similar to those of other arboviruses, particularly dengue. Furthermore, most cases occurred in association with DENV-2. Further phylogenetic studies are needed to evaluate MAYV, which has not been widely examined. |
| Databáze: | OpenAIRE |
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