Dimers, leucine zippers and DNA-binding domains
| Autor: | Steven J. Busch, Paolo Sassone-Corsi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
ATF3
Leucine zipper Molecular Sequence Data Protein domain bZIP domain Basic helix-loop-helix leucine zipper transcription factors DNA DNA-binding domain Biology Gene Expression Regulation Biochemistry Leucine Transcription (biology) Sequence Homology Nucleic Acid Genetics Amino Acid Sequence Transcription factor Transcription Factors |
| Zdroj: | Trends in Genetics. 6:36-40 |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/0168-9525(90)90071-d |
| Popis: | Transcription factors can be divided into classes on the basis of their mode of interaction with the target promoter sequence. Different protein domains responsible for DNA recognition have been identified. In this review we discuss the leucine zipper structure, which has been found in several nuclear factors, including the oncoproteins Fos and Jun. Structural considerations are summarized to help understand how dimerization is mediated by the leucine zipper and how this is the prerequisite for optimal target DNA recognition by the adjacent basic domains. |
| Databáze: | OpenAIRE |
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