Kernicterus in an Adult Dog
| Autor: | D. L. Montgomery, C. K. Stevenson, C. R. Sangster, Andrew L. Allen, Beverly A. Kidney |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Necrosis 040301 veterinary sciences Kitten 0403 veterinary science 03 medical and health sciences Yellow discoloration Dogs Fulminant hepatic failure Cerebellum biology.animal Abdomen medicine Animals Dog Diseases Kernicterus General Veterinary biology business.industry 04 agricultural and veterinary sciences medicine.disease TYPE II ASTROCYTES 030104 developmental biology Liver Foal Thalamic Nuclei Female Spayed Female medicine.symptom business |
| Zdroj: | Veterinary Pathology. 44:383-385 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1354/vp.44-3-383 |
| Popis: | A 7-year-old, spayed female, Wheaton terrier dog was icteric, lethargic, and anorexic with increased activity of hepatocellular and cholestatic liver enzymes and an extreme hyperbilirubinemia level of 609 μmol/L (reference interval: 1.0–4.0 μmol/L). Necropsy findings included profound icterus and red and yellow mottling of the liver. Yellow discoloration of the thalamic and subthalamic nuclei was detected on subgross examination of the formalin-fixed brain. Histologic examination of the brain revealed neuronal necrosis within the discolored nuclei, necrosis of Purkinje cells, and Alzheimer type II astrocytes in the cerebrocortical gray matter and in the nuclei, with gross discoloration. Histologic examination of the liver revealed extensive necrosis in a periacinar-to-bridging pattern and often extending to portal triads. A case of naturally occurring kernicterus in an adult dog secondary to extreme hyperbilirubinemia resulting from fulminant hepatic failure is reported. The few reports of this disease in domestic species involved neonates, namely 1 foal and 1 kitten. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|