Citric Acid Capped Iron Oxide Nanoparticles as an Effective MALDI Matrix for Polymers
| Autor: | Thomas Macher, Carolyn J. Cassady, Qiaoli Liang, Yuping Bao, Jennifer Sherwood, Joseph M. Wilson |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Polydimethylsiloxane Chemistry 010401 analytical chemistry Inorganic chemistry Iron oxide Nanoparticle Polymer 010402 general chemistry Mass spectrometry 01 natural sciences 0104 chemical sciences Matrix (chemical analysis) chemistry.chemical_compound Polypropylene glycol Chemical engineering Structural Biology Citric acid Spectroscopy |
| Zdroj: | Journal of the American Society for Mass Spectrometry. 28:409-418 |
| ISSN: | 1044-0305 |
| DOI: | 10.1007/s13361-016-1560-4 |
| Popis: | A new matrix-assisted laser desorption ionization (MALDI) mass spectrometry matrix is proposed for molecular mass determination of polymers. This matrix contains an iron oxide nanoparticle (NP) core with citric acid (CA) molecules covalently bound to the surface. With the assistance of additives, the particulate nature of NPs allows the matrix to mix uniformly with polar or nonpolar polymer layers and promotes ionization, which may simplify matrix selection and sample preparation procedures. Several distinctively different polymer classes (polyethyleneglycol (PEG), polywax/polyethylene, perfluoropolyether, and polydimethylsiloxane) are effectively detected by the water or methanol dispersed NPCA matrix with NaCl, NaOH, LiOH, or AgNO3 as additives. Furtheremore, successful quantitative measurements of PEG1000 using polypropylene glycol 1000 as an internal standard are demonstrated. |
| Databáze: | OpenAIRE |
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