MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven

Autor: N W Rayner, Christopher Holmes, Josine L. Min, Mark I. McCarthy, George Nicholson, Blanca M. Herrera, Krina T. Zondervan, Mattias Rantalainen, Amy Barrett, Matt J. Neville, Maxine Allen, Quin F. Wills, Rory Bowden, Jan Fleckner, Cecilia M. Lindgren, Fredrik Karpe
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
lcsh:Medicine
Adipose tissue
Gene Expression
Genome-wide association study
0302 clinical medicine
Gene expression
lcsh:Science
Oligonucleotide Array Sequence Analysis
Metabolic Syndrome
0303 health sciences
Multidisciplinary
Genomics
Functional Genomics
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Genotype
Quantitative Trait Loci
Abdominal Fat
030209 endocrinology & metabolism
Biology
Quantitative trait locus
Polymorphism
Single Nucleotide
Andrology
03 medical and health sciences
Molecular genetics
microRNA
medicine
Genetics
Humans
RNA
Messenger
Obesity
030304 developmental biology
Nutrition
Gene Expression Profiling
lcsh:R
Molecular biology
Gene expression profiling
MicroRNAs
Case-Control Studies
Metabolic Disorders
Expression quantitative trait loci
Buttocks
lcsh:Q
Genome Expression Analysis
Biomarkers
Follow-Up Studies
Genome-Wide Association Study
Zdroj: PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27338 (2011)
Popis: To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miRNAs were differentially expressed between these tissues. We found that 12% of the miRNAs were significantly differentially expressed between abdominal and gluteal adipose tissue (FDR adjusted p
Databáze: OpenAIRE
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