Intracranial arteriovenous malformations treated with LINAC-based conformal radiosurgery: validation of the radiosurgery-based arteriovenous malformation score as a predictor of outcome
| Autor: | Miguel Angel Celis, J. M. Lárraga‐Gutiérrez, Mariana Hernández-Bojórquez, Guillermo Axayacalt Gutiérrez-Aceves, José de Jesús Suárez-Campos, Sergio Moreno-Jiménez, Amanda Garcia-Garduñno |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male medicine.medical_specialty Adolescent medicine.medical_treatment Radiation Dosage Radiosurgery Disability Evaluation Predictive Value of Tests Outcome Assessment Health Care medicine Humans In patient Child business.industry Significant difference Reproducibility of Results Arteriovenous malformation General Medicine Middle Aged medicine.disease Treatment Outcome Neurology Female Neurology (clinical) Radiology business Follow-Up Studies |
| Zdroj: | Neurological research. 29(7) |
| ISSN: | 0161-6412 |
| Popis: | To validate the radiosurgery-based arteriovenous malformation score (RBAS) as a predictor of outcome in patients with arteriovenous malformations (AVMs) treated with LINAC-based conformal radiosurgery.We analysed 40 patients with a mean follow-up of 22 months. One patient (2.5%) pertained to Spetzler-Martin Grade I, 11 (27.5%) to Grade II, 19 (47.5%) to Grade III, eight (20%) to Grade IV and one (2.5%) to grade V. The mean RBAS was 2.0 (range: 0.76-5.56). The mean obliteration prediction index (OPI) and the Karlsson index (KI) were 0.74 (range: 0.2-2.86) and 109.48 (range: 3.0-350.7) respectively. Outcomes were analysed according to the OPI, KI and RBAS.We analysed different cutoff points in the RBAS and found a significant difference to predict the outcome in four scores: 1.2, 1.6, 1.7 and 1.8. In the group with RBASor = 1.8, 13 (68%) had an excellent outcome and six (33%) did not, while with RBAS1.8, seven (32%) had an excellent outcome and 14 (67%) did not (p = 0.02). We did not find any correlation between Spetzler-Martin grading scale or OPI and outcome (p = 0.7 and p = 0.3 respectively). The KI predicted the excellent outcome in 8/9 patients (89%) with KIor = 27 and in 12/31 patients (39%) with KI27 (p = 0.08).The RBAS seems to be a good predictor of outcome in patients with AVMs treated with LINAC-based conformal radiosurgery as in patients treated with Gamma Knife. It remains only to find the best cutoff point based on a larger series and longer follow-up. |
| Databáze: | OpenAIRE |
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