Traumatic Brain Injury Elevates the Alzheimer's Amyloid Peptide Abeta42 in Human CSF: A Possible Role for Nerve Cell Injury
| Autor: | Charlotte Raby, Alex E. Roher, P. F. Stahel, Lori M. Evans, Katharyn Spiegel, Mark R. Emmerling, T. Kossmann, Yu Min Kuo, P. D. Mehta, M. C. Morganti-Kossmann, M. D. Watson |
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| Rok vydání: | 2000 |
| Předmět: |
Apolipoprotein E
Pathology medicine.medical_specialty Traumatic brain injury Cell Enolase tau Proteins Inflammation Blood–brain barrier General Biochemistry Genetics and Molecular Biology Cohort Studies Amyloid beta-Protein Precursor Cerebrospinal fluid History and Philosophy of Science Alzheimer Disease Risk Factors Transforming Growth Factor beta medicine Humans Dementia Amyloid beta-Peptides Interleukin-6 Tumor Necrosis Factor-alpha General Neuroscience Interleukin-8 medicine.disease Peptide Fragments medicine.anatomical_structure nervous system Blood-Brain Barrier Brain Injuries Phosphopyruvate Hydratase Cytokines medicine.symptom Psychology Biomarkers Acute-Phase Proteins |
| Zdroj: | Annals of the New York Academy of Sciences. 903:118-122 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2000.tb06357.x |
| Popis: | The increased risk for Alzheimer's Disease (AD) associated with traumatic brain injury (TBI) suggests that environmental insults may influence the development of this age-related dementia. Recently, we have shown that the levels of the beta-amyloid peptide (A beta 1-42) increase in the cerebrospinal fluid (CSF) of patients after severe brain injury and remain elevated for some time after the initial event. The relationships of elevated A beta with markers of blood-brain barrier (BBB) disruption, inflammation, and nerve cell or axonal injury were evaluated in CSF samples taken daily from TBI patients. This analysis reveals that the rise in A beta 1-42 is best correlated with possible markers of neuronal or axonal injury, the cytoskeletal protein tau, neuron-specific enolase (NSE), and apolipoprotein E (ApoE). Similar or better correlations were observed between A beta 1-40 and the three aforementioned markers. These results imply that the degree of brain injury may play a decisive role in determining the levels of A beta 1-42 and A beta 1-40 in the CSF of TBI patients. Inflammation and alterations in BBB may play lesser, but nonetheless significant, roles in determining the A beta level in CSF after brain injury. |
| Databáze: | OpenAIRE |
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