Demineralized and decellularized bone extracellular matrix-incorporated electrospun nanofibrous scaffold for bone regeneration
| Autor: | Guobao Chen, Yonggang Lv, Chanjuan Dong, Fangyu Qiao |
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| Rok vydání: | 2021 |
| Předmět: |
Bone Regeneration
Polyesters Cell Biomedical Engineering Nanofibers Biocompatible Materials Bone and Bones Extracellular matrix Rats Sprague-Dawley In vivo Osteogenesis Materials Testing medicine Animals General Materials Science Particle Size Bone regeneration Cells Cultured Cell Proliferation Decellularization Tissue Scaffolds Chemistry Mesenchymal stem cell technology industry and agriculture Cell Differentiation Mesenchymal Stem Cells General Chemistry General Medicine In vitro Cell biology Extracellular Matrix Rats medicine.anatomical_structure Nanofibrous scaffold |
| Zdroj: | Journal of materials chemistry. B. 9(34) |
| ISSN: | 2050-7518 |
| Popis: | Extracellular matrix (ECM)-based materials have been employed as scaffolds for bone tissue engineering, providing a suitable microenvironment with biophysical and biochemical cues for cell attachment, proliferation and differentiation. In this study, bone-derived ECM (bECM)-incorporated electrospun poly(e-caprolactone) (PCL) (bECM/PCL) nanofibrous scaffolds were prepared and their effects on osteogenesis were evaluated in vitro and in vivo. The results showed that the bECM/PCL scaffolds promoted the attachment, spreading, proliferation and osteogenic differentiation of rat mesenchymal stem cells (MSCs), mitigated the foreign-body reaction, and facilitated bone regeneration in a rat calvarial critical size defect model. Thus, this study suggests that bECM can provide a promising option for bone regeneration. |
| Databáze: | OpenAIRE |
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