Generation of Electrospun Nanofibers with Controllable Degrees of Crimping through a Simple, Plasticizer-based Treatment
| Autor: | Christine H. Moran, Justin Lipner, Stavros Thomopoulos, Younan Xia, Xiyu Li, Liangzhu Feng, Wenying Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Cell Survival Polymers Polyesters Nanofibers Tendon tissue Spectrum Analysis Raman Article Tendons Polylactic Acid-Polyglycolic Acid Copolymer Electrospun nanofibers Biomimetic Materials Plasticizers Elastic Modulus Materials Testing medicine General Materials Science Lactic Acid Composite material Shrinkage chemistry.chemical_classification Calorimetry Differential Scanning Ethanol Tissue Scaffolds Mechanical Engineering technology industry and agriculture Plasticizer Dimethylformamide Polymer Fibroblasts musculoskeletal system Tendon Polyester medicine.anatomical_structure chemistry Mechanics of Materials Nanofiber Microscopy Electron Scanning Polyvinyls Polyglycolic Acid |
| Popis: | A method was developed for generating crimped features in uniaxially aligned electrospun nanofibers to mimic the anatomic structure of collagen fibrils in tendon tissues. We demonstrated that nanofibers comprised of poly(lactic acid) (PLA) and its copolymers or blends would shrink to generate crimped features along the fiber axis when the sample was treated with ethanol. The degree of crimping could be readily controlled by pre-setting the extent of shrinkage allowed for the fibers. As indicated by results from both Raman spectroscopy and differential scanning calorimetry, the crimping was a result of the energy released from the residual stress contained in the electrospun nanofibers. Tensile testing indicates that the crimped nanofibers had a non-linear stiffening behavior with increasing strain, resembling the mechanical behavior of native tendon. In addition, the crimped nanofibers were able to provide better protection to the attached tendon fibroblasts under uniaxial strains when compared to their straight counterparts. Taken together, the crimped nanofibers present a promising new platform for tendon tissue engineering. |
| Databáze: | OpenAIRE |
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