5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection
| Autor: | Shamim I. Ahmad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Deoxyribonucleosides Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral Disease medicine.disease_cause Article Drug Administration Schedule Virus Betacoronavirus 03 medical and health sciences 0302 clinical medicine Pandemic medicine Humans Intensive care medicine Pandemics Coronavirus Inflammation Clinical Trials as Topic Alanine Deoxyribose SARS-CoV-2 business.industry COVID-19 Chloroquine Drug Synergism General Medicine Models Theoretical Adenosine Monophosphate COVID-19 Drug Treatment 030104 developmental biology Fluorouracil Coronavirus Infections business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Medical Hypotheses |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2020.109754 |
| Popis: | The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will continue and how much more destruction it is going to cause until complete control is achieved. One of the most disturbing issues is Covid-19 treatment; although a large number of medications, previously used successfully with other viruses (including Chinese herbal medicines and anti-malaria drugs), are under consideration, there remain questions as to whether they can play a satisfactory role for this disease. Global attempts are ongoing to find the drugs for the treatment of this virus but none of the antiviral drugs used for treatment of other human viral infection is working and hence attempts to find new drugs are continuing. Here the author is proposing that 5-Fluorouracil (5-FU) which when used on its own is failing as an antiviral agent due to the removal of this compound by proof reading ability exceptionally found in Coronaviruses. The author here is proposing to test 5-FU in combination with a number of deoxynucleosides on animal models infected with this Covid-19. Should encouraging results ensue, therapies could then be tried on patients. |
| Databáze: | OpenAIRE |
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