Motor Clusters Reveal Differences in Risk for Psychosis, Cognitive Functioning, and Thalamocortical Connectivity: Evidence for Vulnerability Subtypes
| Autor: | Sebastian Walther, Vijay A. Mittal, Derek J. Dean, Jessica A. Bernard |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Psychosis
business.industry Vulnerability Cognition medicine.disease Article 030227 psychiatry 03 medical and health sciences Clinical Psychology 0302 clinical medicine medicine Etiology Personalized medicine Cognitive skill Young adult 610 Medicine & health business Risk assessment Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Clinical Psychological Science. 6:721-734 |
| ISSN: | 2167-7034 2167-7026 |
| DOI: | 10.1177/2167702618773759 |
| Popis: | Abnormal development of parallel cortical-striatal networks may contribute to abnormal motor, cognitive, and affective behavior prior to the onset of psychosis. Partitioning individuals at clinical high risk (CHR) using motor behavior may provide a novel perspective on different etiological pathways or patient subtypes. A k-means cluster analysis was conducted in CHR ( N = 69; 42% female, mean age = 18.67 years) young adults using theoretically distinct measures of motor behavior. The resulting subtypes were then compared on positive and negative symptoms at baseline, and 2-year risk of psychosis conversion. CHR participants were followed for 2 years to determine conversion to psychosis. CHR subtypes and healthy controls ( n = 61; 57% female, mean age = 18.58 years) were compared on multiple cognitive domains and cortical-striatal connectivity. Results suggest 3 vulnerability subtypes of CHR individuals with different profiles of motor performance, symptoms, risk for conversion to psychosis, cognition, and thalamocortical connectivity. This approach may reflect a novel strategy for promoting tailored risk assessment as well as future research developing individualized medicine. |
| Databáze: | OpenAIRE |
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