Ground-State Proton-Transfer (GSPT)-Assisted Enhanced Two-Photon Uncaging from a Binol-based AIE-Fluorogenic Phototrigger

Autor:	MOUMITA KUNDU, SOMNATH MAJI, Bipul Pal, N D Pradeep Singh, Somnath Maji, Biswajit Gopal Roy, Dr. Biswajit Roy, Mahitosh Mandal
Rok vydání:	2021
Předmět:	Proton Two-photon excitation microscopy 010405 organic chemistry Chemistry Organic Chemistry Physical and Theoretical Chemistry 010402 general chemistry Ground state Photochemistry 01 natural sciences Biochemistry 0104 chemical sciences
Zdroj:	Organic Letters. 23:2308-2313
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c00445
Popis:	We demonstrated for the first time without any chemical modification the two-photon absorption (TPA) cross-section can be enhanced and red-shifted to the near-infrared (NIR) region by the ground-state proton-transfer (GSPT) process. Using GSPT, we developed a simple binol-based aggregation-induced emission (AIE)-fluorogenic phototrigger having a large two-photon uncaging cross-section in the "phototherapeutic window". As a proof of concept, we showed our phototrigger for the release of two different anticancer drugs in the NIR region.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6933b2bc7117bd6c6a75b7676108c72d https://doi.org/10.1021/acs.orglett.1c00445 Zobrazit plný text záznamu