Role of antimicrobial peptides system in inflammatory periodontal diseases non-specific oral cavity protection
| Autor: | E. N. Bashilova, S N Pisareva, S Yu Lepeshkin, A S Galieva, N. V. Davidovich, T. A. Bazhukova, N. V. Solovieva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Periodontium
Pore Forming Cytotoxic Proteins 0301 basic medicine medicine.medical_treatment Antimicrobial peptides medicine.disease_cause Aggregatibacter actinomycetemcomitans Cathelicidin 03 medical and health sciences Gingivitis 0302 clinical medicine medicine Bacteroides Humans Periodontal Pocket Periodontitis business.industry Biochemistry (medical) Gingival Pocket Pathogenic bacteria 030206 dentistry General Medicine medicine.disease Chronic periodontitis Medical Laboratory Technology 030104 developmental biology Chronic Periodontitis Immunology medicine.symptom business Porphyromonas gingivalis |
| Zdroj: | Russian Clinical Laboratory Diagnostics. 66:422-427 |
| ISSN: | 2412-1320 0869-2084 |
| DOI: | 10.51620/0869-2084-2021-66-7-422-427 |
| Popis: | The system of antimicrobial peptides (AMP) is one of the most ancient mechanisms of the macroorganism resistance to infectious pathogens invasion. The aim of the study was to determine the role of the antimicrobial peptides system and periodontal pathogenic markers in the development and progression of inflammatory periodontal diseases. Gingival pocket washes (91 samples in total) for the research were received from patients with inflammatory periodontal diseases (chronic periodontitis and gingivitis) and intact periodontium. Using ELISA, the content of antimicrobial peptides was determined: human alpha-defensin (HNP 1-3), beta-defensin (HBD 1-3) and cathelicidin (LL-37). Periodontal pathogenic markers were isolated during RT-PCR. The study revealed differences in AMP concentrations by groups: level of HBD 2 in patients with chronic periodontitis was 1,36 times higher than those in the group of patients with chronic gingivitis (p=0,023) and 2,39 times higher than those in the control group (p |
| Databáze: | OpenAIRE |
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