Epidemiology, diagnosis and treatment of the malignant pleural mesothelioma, a narrative review of literature
| Autor: | Sven Oliver Schumann, Gregor J. Kocher, Fabrizio Minervini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Extrapleural Pneumonectomy Oncology medicine.medical_specialty medicine.medical_treatment 610 Medicine & health Review Article 030204 cardiovascular system & hematology medicine.disease_cause Asbestos 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Mesothelioma Chemotherapy business.industry Cancer medicine.disease respiratory tract diseases Radiation therapy 030220 oncology & carcinogenesis Narrative review business |
| Zdroj: | Schumann, Sven Oliver; Kocher, Gregor; Minervini, Fabrizio (2021). Epidemiology, diagnosis and treatment of the malignant pleural mesothelioma, a narrative review of literature. Journal of thoracic disease, 13(4), pp. 2510-2523. AME Publishing Company 10.21037/jtd-20-2761 J Thorac Dis |
| DOI: | 10.21037/jtd-20-2761 |
| Popis: | The malignant pleural mesothelioma is a very aggressive tumor which is arising from mesothelial cells and is associated with asbestos exposure. It is a heterogeneous cancer that shows a complex pattern of molecular changes, including genetic, chromosomic, and epigenetic abnormalities. The malignant pleural mesothelioma is characterized by a silent and slow clinical progression with an average period of 20-40 years from the asbestos exposure phase to the start of the symptoms. Unfortunately, to date, the therapeutic options are very limited, especially if the tumor is detected late. This narrative review provides an extended overview of the present evidence in the literature regarding the epidemiology, diagnostic pathways and treatment approaches of the malignant pleural mesothelioma. The treatment of mesothelioma has evolved slowly over the last 20 years not only from a surgical point of view but also radiotherapy, chemotherapy and immunotherapy play nowadays a key role. Several surgical strategies are available ranging from extrapleural pneumonectomy to cytoreductive surgery but a multidisciplinary approach seems to be mandatory because a single approach has not proved to date to be resolutive. New non-surgical treatment options appear to be promising but the results have to be taken in account with caution because clear evidence with high-quality studies is still lacking. |
| Databáze: | OpenAIRE |
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