Influence of the metabolic syndrome on aortic stiffness in never treated hypertensive patients

Autor: Giovanni Mezzatesta, Emilio Nardi, Vito Volpe, Rosalia Mongiovì, Giuseppe Mulè, Paola Cusimano, Giuseppe Andronico, Giovanna Seddio, Giovanni Cerasola, G. Piazza, Santina Cottone
Přispěvatelé: MULE' G, COTTONE S, MONGIOVI' R, CUSIMANO P, MEZZATESTA G, SEDDIO G, VOLPE V, NARDI E, ANDRONICO G, PIAZZA G, CERASOLA G
Rok vydání: 2006
Předmět:
Arterial hypertension
Adult
Male
medicine.medical_specialty
Settore MED/09 - Medicina Interna
Ambulatory blood pressure
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Essential hypertension
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Albuminuria
Humans
Pulse wave velocity
National Cholesterol Education Program
Aorta
Metabolic Syndrome
Nutrition and Dietetics
business.industry
Age Factors
Blood Pressure Monitoring
Ambulatory
Middle Aged
Cardiovascular risk
medicine.disease
Settore MED/11 - Malattie Dell'Apparato Cardiovascolare
Elasticity
Femoral Artery
Aortic stiffne
Carotid Arteries
Blood pressure
Endocrinology
Diabetes Mellitus
Type 2
Blood chemistry
Case-Control Studies
Hypertension
Cardiology
Regression Analysis
Female
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 16:54-59
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2005.03.005
Popis: Summary Background and aim Metabolic syndrome (MS) carries an increased risk for cardiovascular events and there is a growing awareness that large artery stiffening is a powerful predictor of cardiovascular morbidity and mortality. Little is known about the relationship of MS with aortic stiffness. The aim of our study was to analyze, in patients with essential hypertension, the influence of MS, defined according to the criteria proposed by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III), on carotid–femoral pulse wave velocity (PWV), a measure of aortic stiffness. Methods Ninety-three untreated essential hypertensives, aged between 23 and 61 years, without diabetes mellitus, were studied. All subjects underwent routine blood chemistry, oral glucose tolerance test with glucose and insulin determinations, albumin excretion rate (AER) measurement, 24-h ambulatory blood pressure monitoring, and measurement of carotid–femoral PWV, by means of a computerized method. Results Patients with MS (n = 28) showed higher age-adjusted carotid–femoral PWV (10.1 ± 1.4 vs 9.3 ± 1.4 m/s; p = 0.01) when compared to subjects without MS. This difference held after controlling for gender and for 24-h mean blood pressure (MBP) (p = 0.02) and lost its statistical significance after further adjustment for AER. In a multiple regression model, excluding the individual components of MS, in which metabolic syndrome was added along with age, gender, smoking habit, LDL cholesterol, HOMA index, 24-h MBP and 24-h heart rate, MS remained independently associated with carotid-femoral PWV (β = 0.29; p = 0.002). The statistical significance of this association disappeared after the inclusion into this model of AER. Conclusions Metabolic syndrome is associated with an increased aortic stiffness. Main explanatory factors of this association are age, systolic blood pressure and albumin excretion rate.
Databáze: OpenAIRE
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