HAIRY-like Transcription Factors and the Evolution of the Nematode Vulva Equivalence Group
| Autor: | Min Zheng, Waltraud Röseler, Ralf J. Sommer, Arturo Gutierrez, Benjamin Schlager |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
animal structures
Nematoda Molecular Sequence Data ved/biology.organism_classification_rank.species DEVBIO Apoptosis Biology General Biochemistry Genetics and Molecular Biology Vulva Equivalence group Basic Helix-Loop-Helix Transcription Factors Animals Amino Acid Sequence Caenorhabditis elegans Hox gene Gene Homeodomain Proteins Genetics Base Sequence Agricultural and Biological Sciences(all) urogenital system ved/biology Biochemistry Genetics and Molecular Biology(all) Panagrellus redivivus Helix-Loop-Helix Motifs fungi ECO_EVOL Gene Expression Regulation Developmental Cell Differentiation Helminth Proteins biology.organism_classification Biological Evolution Phenotype female genital diseases and pregnancy complications Protein Structure Tertiary Repressor Proteins Caenorhabditis Pristionchus pacificus Mutation Female General Agricultural and Biological Sciences Sequence Alignment |
| Zdroj: | Current Biology. 16(14):1386-1394 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2006.06.058 |
| Popis: | Summary Background Nematode vulva formation provides a paradigm to study the evolution of pattern formation and cell-fate specification. The Caenorhabditis elegans vulva is generated from three of six equipotent cells that form the so-called vulva equivalence group. During evolution, the size of the vulva equivalence group has changed: Panagrellus redivivus has eight, C. elegans six, and Pristionchus pacificus only three cells that are competent to form vulval tissue. In P. pacificus, programmed cell death of individual vulval precursor cells alters the size of the vulva equivalence group. Results We have identified the genes controlling this cell-death event and the molecular mechanism of the reduction of the vulva equivalence group. Mutations in Ppa-hairy , a gene that is unknown from C. elegans , result in the survival of two precursor cells, which expands the vulva equivalence group. Mutations in Ppa-groucho cause a similar phenotype. Ppa -HAIRY and Ppa -GROUCHO form a molecular module that represses the Hox gene Ppa-lin-39 and thereby reduces the size of the vulva equivalence group. The C. elegans genome does not encode a similar hairy -like gene, and no typical HAIRY/GROUCHO module exists. Conclusions We conclude that the vulva equivalence group in Pristionchus is patterned by a HAIRY/GROUCHO module, which is absent in Caenorhabditis . Thus, changes in the number, structure, and function of nematode hairy -like transcription factors are involved in the evolutionary alteration of this equivalence group. |
| Databáze: | OpenAIRE |
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