Pharmacokinetics of oral cibenzoline in arrhythmia patients
| Autor: | John C. Somberg, Paul J. Block, Alice J. Szuna, Nathan H. Carliner, Roger A. Winkle, Romulus K. Brazzell, Keiko Aogaichi, James J. Heger, Joel Morganroth, Wayne A. Colburn |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Renal function Administration Oral Models Biological chemistry.chemical_compound Elimination rate constant Pharmacokinetics Oral administration Internal medicine Medicine Humans Pharmacology (medical) Dosing Aged Pharmacology Creatinine Chemotherapy business.industry Imidazoles Arrhythmias Cardiac Middle Aged Kinetics chemistry Anesthesia Cibenzoline Cardiology Drug Evaluation Female business Anti-Arrhythmia Agents Mathematics |
| Zdroj: | Clinical pharmacokinetics. 10(2) |
| ISSN: | 0312-5963 |
| Popis: | The pharmacokinetics of oral cibenzoline were studied in 30 arrhythmia patients as part of an ascending multiple-dose efficacy study. The elimination half-life of the drug following repetitive dosing ranged from 7.6 to 22.3 hours, with a harmonic mean of 12.3 hours (n = 24), and increased with age and decreasing renal function. The drug exhibited apparent dose proportional and linear pharmacokinetics over the range of doses studied. Multivariate analysis revealed that the patients' age and serum creatinine concentration accounted for 71% of the variability in the range of beta values (terminal elimination rate constant), and that 69.5% of the intersubject variability in the steady-state trough plasma concentrations could be accounted for by the patients' age, weight and serum creatinine concentration. These data suggest that, although there is some intersubject variability in the elimination and accumulation of cibenzoline, much of the variability can be explained by the patients' age, weight and renal function. |
| Databáze: | OpenAIRE |
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