Early Response of Hepatocellular Carcinoma to Chemoembolization: Volume Computed Tomography Liver Perfusion Imaging as a Short-Term Response Predictor
| Autor: | Wen He, Long Jin, Guo-Wen Xiao, Guang Chen, Tianhao Su |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Hemodynamics Perfusion scanning 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Multidetector Computed Tomography medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Prospective Studies Chemoembolization Therapeutic Aged Retrospective Studies Aged 80 and over business.industry Therapeutic effect Liver Neoplasms Middle Aged medicine.disease Portal vein thrombosis Treatment Outcome Liver Hepatocellular carcinoma 030211 gastroenterology & hepatology Female Radiology business Perfusion Tomography Spiral Computed Progressive disease Follow-Up Studies |
| Zdroj: | Journal of computer assisted tomography. 41(2) |
| ISSN: | 1532-3145 |
| Popis: | Objective The aim of this study was to investigate the efficacy of lesion-oriented whole-liver computed tomography (CT) perfusion for predicting transarterial chemoembolization early treatment response in patients with hepatocellular carcinoma (HCC). Methods Volume helical shuttle CT perfusion imaging on the whole liver was prospectively performed on 39 patients with 46 independent HCC lesions before target-selected chemoembolization. The therapeutic effects were assessed: responder group included lesions with a complete and partial response, whereas the nonresponder group contained stable and progressive disease. The perfusion parameter value comparison between 2 groups and receiver operating characteristic analyses were performed. Results The responders demonstrated higher hepatic arterial perfusion (HAP) and hepatic arterial perfusion index (HAPI) and lower hepatic portal perfusion (HPP) compared with the nonresponders among the 34 lesions without Vp3 or Vp4 portal vein thrombosis. In addition, HAP and HAPI had good prognostic values. Conclusions Whole-liver CT perfusion allows for hemodynamic evaluation of HCC lesions. The HAP, HAPI, and hepatic portal perfusion values may be useful predictors of short-term therapeutic response after transarterial chemoembolization. |
| Databáze: | OpenAIRE |
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