β1-Adrenergic blockade during cardiopulmonary resuscitation improves survival
| Autor: | Shijie Sun, Wanchun Tang, Gianluca Cammarata, Lei Huang, Jinglan Wang, Max Harry Weil |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Defibrillation medicine.medical_treatment Adrenergic beta-Antagonists In Vitro Techniques Antiarrhythmic agent Critical Care and Intensive Care Medicine Propanolamines Rats Sprague-Dawley Intensive care Internal medicine medicine Animals Cardiopulmonary resuscitation Mechanical ventilation business.industry Esmolol medicine.disease Cardiopulmonary Resuscitation Rats Anesthesia Ventricular Fibrillation Ventricular fibrillation Cardiology business medicine.drug |
| Zdroj: | Critical Care Medicine. 32:S440-S443 |
| ISSN: | 0090-3493 |
| Popis: | Objective: The short-acting β 1 -selective adrenergic blocking agent, esmolol, was administrated during cardiopulmonary resuscitation with the hypothesis that initial resuscitation and postresuscitation survival would be improved. Design: Prospective, randomized, controlled study Setting: Animal research laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Ventricular fibrillation was induced in 18 male Sprague-Dawley rats, which were then left untreated for 6 mins before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation. Animals were randomized to receive 300 μg/kg esmolol in a volume of 200 μL or an equivalent volume of saline placebo during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 12 mins of ventricular fibrillation. Measurements and Main Results: Esmolol-treated animals required a significantly smaller number of electrical shocks before resuscitation. Each of the esmolol-treated but only five of nine placebo-treated animals were successfully resuscitated. Postresuscitation contractile and left ventricular diastolic functions of resuscitated animals were significantly better after esmolol administration and duration of survival was significantly increased. Conclusions: A short-acting β 1 -selective adrenergic blocking agent, when administered during cardiopulmonary resuscitation, significantly improved initial cardiac resuscitation, minimized postresuscitation myocardial dysfunction, and increased the duration of postresuscitation survival. |
| Databáze: | OpenAIRE |
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