Preclinical verification of the efficacy by targeting peptide-linked liposomal nanoparticles for hepatocellular carcinoma therapy
Autor: | Chih-Feng Lin, Chin-Tarng Lin, Ming-Chen Hsu, Cheng-Der Wu, Chung-Wei Lee, Hang-Chung Wu, Jen-Chieh Lee |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Hepatocellular carcinoma
medicine.medical_treatment Biomedical Engineering lcsh:Medicine Peptide Cell membrane 03 medical and health sciences 0302 clinical medicine Medicine Original Research Article SP-94-peptide Adverse effect 030304 developmental biology chemistry.chemical_classification 0303 health sciences Chemotherapy Liposome business.industry lcsh:R L-peptide medicine.disease medicine.anatomical_structure chemistry PC5-52-peptide Apoptosis 030220 oncology & carcinogenesis Cancer cell Cancer research peptide-targeted chemotherapy business Biotechnology |
Zdroj: | Nanobiomedicine, Vol 6 (2019) Nanobiomedicine |
ISSN: | 1849-5435 |
Popis: | The purpose of this study was to investigate the efficacy of targeting peptides chemotherapy to overcome adverse event in the conventional chemotherapy for human hepatocellular carcinoma. Previously we reported several cancer-targeting peptides that bind specifically to cancer cells and their vascular endothelia: L-peptide (anti-cancer cell membrane), RLLDTNRPLLPY; SP-94-peptide (anti-hepatoma cell membrane), SFSHHTPILP; PC5-52-peptide (anti-tumor endothelia), SVSVGMKPSPRP; and control peptide, RLLDTNRGGGGG. In this study, these peptides were linked to liposomal iron oxide nanoparticles to localize the targeted tumor cells and endothelia, and to dextran-coated liposomal doxorubicin (L-D) to treat nonobese diabetic severe combined immunodeficient mice bearing hepatoma xenografts. Our results showed that L-peptide-linked liposomal doxorubicin could inhibit tumor growth with very mild adverse events. Use of the control peptide led to a decrease in the xenograft size but also led to marked apoptotic change in the visceral organ. In conclusion, L-peptide-linked liposomal doxorubicin, SP-94-peptide, and PC5-52-peptide can be used for the treatment of hepatoma xenografts in nonobese diabetic severe combined immunodeficient mice with minimal adverse events. |
Databáze: | OpenAIRE |
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