Calcium Metabolism in the Morbidly Obese
| Autor: | Gary J. Anthone, Nahid Hamoui, Peter F. Crookes |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism chemistry.chemical_element Parathyroid hormone Calcium Preoperative care Body Mass Index Internal medicine Preoperative Care medicine Vitamin D and neurology Humans Prospective Studies Vitamin D Prospective cohort study Serum Albumin Aged Calcium metabolism Hyperparathyroidism Nutrition and Dietetics business.industry Middle Aged medicine.disease Obesity Morbid Endocrinology chemistry Parathyroid Hormone Alkaline phosphatase Female Surgery business |
| Zdroj: | Obesity Surgery. 14:9-12 |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1381/096089204772787211 |
| Popis: | Background: Morbidly obese patients are known to have abnormal calcium metabolism compared with the non-obese, but the clinical significance of this is unknown. Since surgical treatment of obesity may itself cause hyperparathyroidism, it is important to understand the preoperative physiology of these patients. Methods: 213 consecutive patients (M 37 : F 176, ages 21-68) presenting for surgical treatment of morbid obesity between October 2000 and June 2002 were prospectively evaluated. Preoperative levels of serum calcium corrected for albumin, alkaline phosphatase, parathyroid hormone (PTH), 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D were measured. We recorded the prevalence of abnormalities in study parameters and correlated them with PTH levels. Results: Hyperparathyroidism (PTH >65 pg/ml) was present in 25.0% of subjects. By contrast, abnormalities of serum calcium were rare. The prevalence of hypocalcemia was 3.5%, and of hypercalcemia was 0.5%. Only 4.3% of patients had increased levels of alkaline phosphatase. 21.1% of patients had abnormally low levels of 25-hydroxyvitamin D (median 15 ng/ml), and 23.1% had increased levels of 1,25-dihydroxyvitamin D (median 49 pg/ml). PTH was positively correlated with BMI (r=.30, P= |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink