Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19
| Autor: | Joseph Eggers, Sophia Siu, Daisy A. Hoagland, Tamar Plitt, Gerold Bongers, Zenab Khan, Marla Dubinsky, Benjamin R. tenOever, Florian Krammer, Alexandra E. Livanos, Francesca Cossarini, Alice Chen-Liaw, Saurabh Mehandru, Divya Jha, Harm van Bakel, Jeremiah J. Faith, Michael Tankelevich, Matthew P. Spindler, Ilaria Mogno, Gustavo Martinez-Delgado, Adriana van de Guchte, Miriam Merad, Lauren Tal Grinspan, Graham J. Britton, Ana S. Gonzalez-Reiche, Rebekah E. Dixon, Fatima Amanat |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Immunoglobulin A Science Article Cohort Studies Feces 03 medical and health sciences 0302 clinical medicine Immune system Nasopharynx Biopsy medicine Humans Microbiome Aged Inflammation Gastrointestinal tract Multidisciplinary biology medicine.diagnostic_test SARS-CoV-2 business.industry Gastrointestinal Microbiome COVID-19 Middle Aged Translational research Diarrhea 030104 developmental biology Immunology biology.protein Cytokines RNA Viral Mucosal immunology Medicine Female New York City 030211 gastroenterology & hepatology Intestinal diseases medicine.symptom Infection business Biomarkers |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports medRxiv article-version (status) pre article-version (number) 1 |
| ISSN: | 2045-2322 |
| Popis: | Background and aims: Immune dysregulation caused by SARS-CoV-2 infection is thought to play a pathogenic role in COVID-19. SARS-CoV-2 can infect a variety of host cells, including intestinal epithelial cells. We sought to characterize the role of the gastrointestinal immune system in the pathogenesis of the inflammatory response associated with COVID-19. Methods: We measured cytokines, inflammatory markers, viral RNA, microbiome composition and antibody responses in stool and serum samples from a prospectively enrolled cohort of 44 hospitalized COVID-19 patients. Results: SARS-CoV-2 RNA was detected in stool of 41% of patients and was found more frequently in patients with diarrhea than those without (16[44%] vs 5[19%], p=0.06). Patients who survived had lower median viral genome copies than those who did not (p=0.021). Compared to uninfected controls, COVID-19 patients had higher median fecal levels of IL-8 (166.5 vs 286.5 pg/mg; p=0.05) and lower levels of fecal IL-10 (678 vs 194 pg/mg; p |
| Databáze: | OpenAIRE |
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