Risk assessment of coumarin using the bench mark dose (BMD) approach: Children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds
| Autor: | Jan Erik Paulsen, Tore Sanner, Jan Alexander, T.Ø. Fotland, Trine Husøy |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cinnamomum zeylanicum Adolescent Avena Liver toxicity Population Toxicology Risk Assessment Young Adult chemistry.chemical_compound Coumarins Adverse health effect Humans Medicine heterocyclic compounds Food science Child education Aged education.field_of_study Dose-Response Relationship Drug Norway business.industry Small children Infant Environmental Exposure General Medicine Environmental exposure Middle Aged Coumarin chemistry Toxicity Female business Risk assessment Food Science |
| Zdroj: | Food and Chemical Toxicology. 50:903-912 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2011.12.005 |
| Popis: | Coumarin is a naturally occurring flavouring substance in cinnamon and many other plants. It is known that coumarin can cause liver toxicity in several species, and it is considered a non-genotoxic carcinogen in rodents. By using the bench mark dose approach we re-assessed coumarin toxicity and established a new TDI for coumarin of 0.07 mg/kg bw/day. Oral intake of coumarin is related to consumption of cinnamon-containing foods and food supplements. Cinnamon is a widely used spice in Norway, and can be used as topping on oatmeal porridge. Based on analyses of coumarin in Norwegian foods, intake calculations for children and adults were conducted, and a risk assessment of coumarin in the Norwegian population was performed. Intake estimates of coumarin show that small children eating oatmeal porridge several times a week sprinkled with cinnamon could have a coumarin intake of 1.63 mg/kg bw/day and may exceeding the TDI with several folds. Adults drinking cinnamon-based tea and consuming cinnamon supplements also can exceed TDI. The coumarin intake could exceed the TDI by 7- to 20-fold in some intake scenarios. Such large daily exceedances of TDI, even for a limited time period of 1-2 weeks, cause concern of adverse health effects. |
| Databáze: | OpenAIRE |
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