Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5

Autor:	Annika Åstrand, Monika Sundqvist, Maria Thorstensson, Tomas Fex, Andreas Nordin, Ahlke Hayen, Annika Björe, Ulrik Gran, Christina Olsson, Johan Sundell, Elin Forsström, Emma Lindhardt, Jonas Boström, Gunilla Linhardt, Teresa Collins, Boel Löfberg, Fanyi Jiang, Roine I. Olsson, Ingemar Jacobson, Anna Öhrn, Karolina Aplander, Olle Hidestål, Jonna Gyll
Rok vydání:	2013
Předmět:	Phosphines Clinical Biochemistry Pharmaceutical Science Biochemistry Inhibitory Concentration 50 Kv1.5 Potassium Channel Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Humans Organic chemistry Structure–activity relationship Molecule Inhibitory concentration 50 Molecular Biology Molecular Structure Diphenylphosphine Chemistry Biphenyl Compounds Organic Chemistry Oxides Amides Phosphinic Acids Combinatorial chemistry Potassium channel nervous system Molecular Medicine Rabbits Selectivity Protein Binding
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 23:706-710
ISSN:	0960-894X
Popis:	Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and several compounds with Kv1.5 IC(50) values of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692644b9777064b4390bd126a7b17fa2 https://doi.org/10.1016/j.bmcl.2012.11.098 Zobrazit plný text záznamu Full Text from ScienceDirect