Autor: |
Annika Åstrand, Monika Sundqvist, Maria Thorstensson, Tomas Fex, Andreas Nordin, Ahlke Hayen, Annika Björe, Ulrik Gran, Christina Olsson, Johan Sundell, Elin Forsström, Emma Lindhardt, Jonas Boström, Gunilla Linhardt, Teresa Collins, Boel Löfberg, Fanyi Jiang, Roine I. Olsson, Ingemar Jacobson, Anna Öhrn, Karolina Aplander, Olle Hidestål, Jonna Gyll |
Rok vydání: |
2013 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 23:706-710 |
ISSN: |
0960-894X |
Popis: |
Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and several compounds with Kv1.5 IC(50) values of |
Databáze: |
OpenAIRE |
Externí odkaz: |
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