Changes in plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors during lethal endotoxin shock in dogs
| Autor: | Michael J. Gallimore, Egil Amundsen, Ansgar O. Aasen |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Circulatory collapse Time Factors High-molecular-weight kininogen Size-exclusion chromatography Endotoxin shock Dogs Physiology (medical) Internal medicine medicine Animals Humans Chemistry Kininogens Prekallikrein Shock Hematology Kallikrein Plasma levels Kallikrein inhibitor medicine.disease Endotoxins Molecular Weight Endocrinology Biochemistry Chromatography Gel Kallikreins circulatory and respiratory physiology |
| Zdroj: | Haemostasis. 7(2-3) |
| ISSN: | 0301-0147 |
| Popis: | Plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors were measured in samples from dogs infused with E. coli endotoxin. Markedly reduced levels of prekallikrein and high molecular weight kininogen were seen at circulatory collapse and free kallikrein was detected. Both ‘fast-reacting’ and ‘time-dependent’ inhibitors of plasma kallikrein were significantly reduced. Fractionation of pre-infusion and collapse samples by gel filtration together with immunological procedures indicated that both α2-macroglobulin and α1-antitrypsin were the major kallikrein inhibitors in dog plasma, and that they were significantly reduced in the collapse samples. |
| Databáze: | OpenAIRE |
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