Urinary epidermal growth factor/monocyte chemotactic peptide 1 ratio as non-invasive predictor of Mayo clinic imaging classes in autosomal dominant polycystic kidney disease

Autor: Rocchetti, M.T., Pesce, F., Matino, S., Piscopo, G., Bari, I. di, Trepiccione, F., Capolongo, G., Perniola, M.A., Song, X.W., Khowaja, S., Haghighi, A., Peters, D., Paolicelli, S., Pontrelli, P., Netti, G.S., Ranieri, E., Capasso, G., Moschetta, M., Pei, Y., Gesualdo, L., Studio PRE MED MED PREcisione Prog
Přispěvatelé: Rocchetti, Maria Teresa, Pesce, Francesco, Matino, Silvia, Piscopo, Giovanni, di Bari, Ighli, Trepiccione, Francesco, Capolongo, Giovanna, Perniola, Maria Antonietta, Song, Xuewen, Khowaja, Saima, Haghighi, Amirreza, Peters, Dorien, Paolicelli, Simona, Pontrelli, Paola, Netti, Giuseppe Stefano, Ranieri, Elena, Capasso, Giovambattista, Moschetta, Marco, Pei, York, Gesualdo, Loreto
Rok vydání: 2022
Předmět:
Zdroj: Journal of Nephrology. SPRINGER HEIDELBERG
Journal of Nephrology
ISSN: 1724-6059
Popis: Background Age- and height-adjusted total kidney volume is currently considered the best prognosticator in patients with autosomal dominant polycystic kidney disease. We tested the ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 for the prediction of the Mayo Clinic Imaging Classes. Methods Urinary epidermal growth factor and monocyte chemotactic peptide 1 levels were measured in two independent cohorts (discovery, n = 74 and validation set, n = 177) and healthy controls (n = 59) by immunological assay. Magnetic resonance imaging parameters were used for total kidney volume calculation and the Mayo Clinic Imaging Classification defined slow (1A–1B) and fast progressors (1C–1E). Microarray and quantitative gene expression analysis were used to test epidermal growth factor and monocyte chemotactic peptide 1 gene expression. Results Baseline ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 correlated with total kidney volume adjusted for height (r = − 0.6, p r = 0.69 p p r = − 0.51, p 132 (100% slow) and p = 6.51E−16). Further, the ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 at baseline showed a positive correlation (p = 0.006, r = 0.36) with renal outcome (delta-estimated glomerular filtration rate per year, over a mean follow-up of 4.2 ± 1.2 years). Changes in the urinary epidermal growth factor and monocyte chemotactic peptide 1 were mirrored by gene expression levels in both human kidney cysts (epidermal growth factor: − 5.6-fold, fdr = 0.001; monocyte chemotactic peptide 1: 3.1-fold, fdr = 0.03) and Pkd1 knock-out mouse kidney (Egf: − 14.8-fold, fdr = 2.37E-20, Mcp1: 2.8-fold, fdr = 6.82E−15). Conclusion The ratio of urinary epidermal growth factor and monocyte chemotactic peptide 1 is a non-invasive pathophysiological biomarker that can be used for clinical risk stratification in autosomal dominant polycystic kidney disease.
Databáze: OpenAIRE
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