Database of cattle candidate genes and genetic markers for milk production and mastitis
Autor: | Peter Dovč, Tanja Kunej, Andrej Razpet, Jernej Ogorevc |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Candidate gene
mammary gland milk traits Mice Transgenic Quantitative trait locus Biology gene linkage computer.software_genre association study mastitis Polymorphism Single Nucleotide Mice Genetic linkage Genetic variation Genetics medicine Animals Lactation Genetic variability Udder Mastitis Bovine Mice Knockout knockout models Database General Medicine Articles medicine.disease Mastitis micro RNA medicine.anatomical_structure Genetic marker quantitative trait loci Animal Science and Zoology Cattle Female methylation candidate genes computer |
Zdroj: | Animal Genetics |
ISSN: | 1365-2052 0268-9146 |
Popis: | Summary A cattle database of candidate genes and genetic markers for milk production and mastitis has been developed to provide an integrated research tool incorporating different types of information supporting a genomic approach to study lactation, udder development and health. The database contains 943 genes and genetic markers involved in mammary gland development and function, representing candidates for further functional studies. The candidate loci were drawn on a genetic map to reveal positional overlaps. For identification of candidate loci, data from seven different research approaches were exploited: (i) gene knockouts or transgenes in mice that result in specific phenotypes associated with mammary gland (143 loci); (ii) cattle QTL for milk production (344) and mastitis related traits (71); (iii) loci with sequence variations that show specific allele-phenotype interactions associated with milk production (24) or mastitis (10) in cattle; (iv) genes with expression profiles associated with milk production (207) or mastitis (107) in cattle or mouse; (v) cattle milk protein genes that exist in different genetic variants (9); (vi) miRNAs expressed in bovine mammary gland (32) and (vii) epigenetically regulated cattle genes associated with mammary gland function (1). Fourty-four genes found by multiple independent analyses were suggested as the most promising candidates and were further in silico analysed for expression levels in lactating mammary gland, genetic variability and top biological functions in functional networks. A miRNA target search for mammary gland expressed miRNAs identified 359 putative binding sites in 3¢UTRs of candidate genes. |
Databáze: | OpenAIRE |
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