Cerebrospinal fluid penetration of cefpirome in patients with non-inflamed meninges
| Autor: | Patricia Mitchell, Howard B. Lassman, John H. Wilton, James L. Budny, Jerome J. Schentag, Norma Velasquez, Kishore Divan, David E. Nix |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Anesthesia Spinal Spinal Puncture Meninges Bolus (medicine) Cerebrospinal fluid Pharmacokinetics Internal medicine medicine Humans Meningitis Pharmacology (medical) Myelography Aged Pharmacology Volume of distribution medicine.diagnostic_test Lumbar puncture business.industry Half-life Cefpirome Middle Aged Cephalosporins Infectious Diseases Endocrinology Anesthesia Cerebrospinal fluid penetration Female business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 29:51-57 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/29.suppl_a.51 |
| Popis: | Twenty patients (mean age 52 +/- 12 years, mean weight 75 +/- 15 kg) scheduled for elective myelogram or spinal anaesthesia were enrolled to determine the cerebrospinal fluid (CSF) penetration of a new expanded spectrum cephalosporin antibiotic, cefpirome (HR-810). A single 2 g intravenous dose of cefpirome was administered as a bolus between 1 and 8 h before lumbar puncture. Blood samples were collected at 15 pre-determined times and a single CSF sample was obtained at the time of lumbar puncture. Serum and CSF cefpirome concentrations were determined by high performance liquid chromatography. The mean maximal serum concentration of cefpirome was 264 +/- 76 mg/L. A mean steady-state volume of distribution of 20 +/- 4 L, clearance of 7.4 +/- 1.3 L/h, and half-life of 2.5 +/- 0.5 h were determined. Mean CSF concentrations were 0.50 +/- 0.11 mg/L at 1-2 h post dose (n = 4), 0.57 +/- 0.13 mg/L at 2-4 h post dose (n = 4), 0.76 +/- 0.34 mg/L at 4-6 h post dose (n = 7), and 0.83 +/- 0.29 mg/L at 6-8.3 h post dose (n = 5). Blood:brain barrier permeability to cefpirome may not be a limiting factor as CSF concentrations were rapidly attained. Further studies are required to determine the mechanism of cefpirome transport between plasma and CSF. |
| Databáze: | OpenAIRE |
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