Cytochemical Studies Demonstrating the Effect of Monosodium Glutamate on RNA Concentration in Neurons in Mice

Autor: Kuldip S. Dhindsa
Rok vydání: 1983
Předmět:
Zdroj: Cells Tissues Organs. 116:201-205
ISSN: 1422-6421
1422-6405
DOI: 10.1159/000145743
Popis: The effect of monosodium glutamate (MSG) on the concentration of ribonucleic acid (RNA) in the neurons of mice was studied, using the specific cytochemical stain, azure B bromide. The RNA-rich sites such as the nucleolus and the Nissl substances of large neurons showed a marked decrease in the concentration of RNA in the MSG-treated as compared to the control animals. Since RNA is believed to be the principal macromolecule involved in the learning and behavioral processes, previous reports have attributed learning and behavioral dysfunctions in MSG-treated animals to a significant decrease of the RNA concentration in these animals.
Databáze: OpenAIRE