Cytochemical Studies Demonstrating the Effect of Monosodium Glutamate on RNA Concentration in Neurons in Mice
Autor: | Kuldip S. Dhindsa |
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Rok vydání: | 1983 |
Předmět: |
Photomicrography
Histology Nucleolus Monosodium glutamate Mice Inbred Strains Biology Azure Stains Stain Mice chemistry.chemical_compound symbols.namesake Glutamates Sodium Glutamate Animals Brain Chemistry Neurons Histocytochemistry RNA Molecular biology chemistry Biochemistry Nissl body symbols Female Anatomy Macromolecule |
Zdroj: | Cells Tissues Organs. 116:201-205 |
ISSN: | 1422-6421 1422-6405 |
DOI: | 10.1159/000145743 |
Popis: | The effect of monosodium glutamate (MSG) on the concentration of ribonucleic acid (RNA) in the neurons of mice was studied, using the specific cytochemical stain, azure B bromide. The RNA-rich sites such as the nucleolus and the Nissl substances of large neurons showed a marked decrease in the concentration of RNA in the MSG-treated as compared to the control animals. Since RNA is believed to be the principal macromolecule involved in the learning and behavioral processes, previous reports have attributed learning and behavioral dysfunctions in MSG-treated animals to a significant decrease of the RNA concentration in these animals. |
Databáze: | OpenAIRE |
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