Selective Adsorption of Proteins on Single-Wall Carbon Nanotubes by Using a Protective Surfactant
| Autor: | Adriele Prina-Mello, Loïc Louise, Arianna Filoramo, Michèle Veber, Stéphane Campidelli, Dominique Langevin, Anton Knyazev |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Nanotube
Cytotoxicity scanning probe microscopy chemistry.chemical_element 02 engineering and technology Carbon nanotube Toxicology 010402 general chemistry 01 natural sciences Catalysis law.invention Mice Immobilization Surface-Active Agents chemistry.chemical_compound Adsorption law Organic chemistry Bifunctional chemistry.chemical_classification Noncovalent Sidewall-Functionalization Pyrenes carbon nanotubes Molecular Structure Nanotubes Carbon Biomolecule Organic Chemistry Water Proteins Serum Albumin Bovine General Chemistry 021001 nanoscience & nanotechnology Pyrrolidinones Diimide-Activated Amidation 0104 chemical sciences Biosensors chemistry Chemical engineering In-Vitro Selective adsorption Human Macrophage Cells 0210 nano-technology Carbon Protein adsorption |
| Zdroj: | Chemistry-A European Journal |
| ISSN: | 0947-6539 |
| DOI: | 10.1002/chem.201101182 |
| Popis: | The dispersion of highly hydrophobic carbon materials such as carbon nanotubes in biological media is a challenging issue. Indeed, the nonspecific adsorption of proteins occurs readily when the nanotubes are introduced in biological media; therefore, a methodology to control adsorption is in high demand. To address this issue, we developed a bifunctional linker derived from pyrene that selectively ena-bles or prevents the adsorption of proteins on single-wall carbon nanotubes (SWNTs). We demonstrated that it is possible to decrease or completely suppress the adsorption of proteins on the nanotube sidewall by using proper functionalization (either covalent or noncovalent). By subsequently activating the functional groups on the nanotube derivatives, protein adsorption can be recovered and, therefore, controlled. Our approach is simple, straightforward, and potentially suitable for other biomolecules that contain thio or amino groups available for coupling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text