Variation of bispectral index under TIVA with propofol in a paediatric population

Autor: Jean-Yves Bansard, Claude Ecoffey, E. Wodey, Lotfi Senhadji, Olivier Tirel, Rupert Harris
Přispěvatelé: Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anesthésie réanimation chirurgicale [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Department of Anaesthesia, St George's Hospital, Senhadji, Lotfi, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou
Rok vydání: 2008
Předmět:
Aging
paediatric
depth
Blood Pressure
0302 clinical medicine
Bolus (medicine)
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing
Heart Rate
030202 anesthesiology
Prospective Studies
Child
i.v
Electroencephalography
anaesthesia
anaesthetics
Child
Preschool
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Anesthesia
Bispectral index
Plasma concentration
pharmacokinetic model
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Propofol
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Anesthetics
Intravenous
remifentanil
medicine.drug
Adolescent
[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing
plasma concentration
Remifentanil
Drug Administration Schedule
Article
03 medical and health sciences
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Pharmacokinetics
Monitoring
Intraoperative
Heart rate
bispectral index
medicine
Humans
[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
[SDV.IB] Life Sciences [q-bio]/Bioengineering
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Dose-Response Relationship
Drug
propofol
business.industry
030208 emergency & critical care medicine
bispectrum
monitoring
Anesthesiology and Pain Medicine
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
business
Paediatric population
Zdroj: British Journal of Anaesthesia
British Journal of Anaesthesia, Oxford University Press (OUP), 2008, 100 (1), pp.82-7. ⟨10.1093/bja/aem339⟩
British Journal of Anaesthesia, 2008, 100 (1), pp.82-7. ⟨10.1093/bja/aem339⟩
ISSN: 0007-0912
1471-6771
DOI: 10.1093/bja/aem339
Popis: International audience; BACKGROUND: In this prospective observational study, we aim to explore the relationship between age and bispectral index (BIS) values at different plasma concentrations of propofol. METHODS: Fifty children aged from 3 to 15 yr were included. Anaesthesia was induced using a target-controlled infusion of propofol with the Kataria pharmacokinetic model together with a bolus of remifentanil followed by a continuous infusion rate at 0.2 microg kg(-1) min(-1). Target plasma propofol concentration was initially stabilized to 6 microg ml(-1) and continued for 6 min. The target was then decreased and stabilized to 4 microg ml(-1) and then to 2 microg ml(-1). BIS values, plasma propofol concentration, and EEG were continuously recorded. In order to explore the relationship between variations in propofol concentration and the EEG bispectrum, we used a multiple correspondence analysis (MCA). Results are shown in median (range). RESULTS: We found no statistical difference between BIS values with propofol 6 microg ml(-1) [23 (12-40)] and 4 microg ml(-1) [28 (9-67)]. At 2 microg ml(-1), BIS was significantly different [52 (24-71)], but a significant correlation between the age of children and BIS values was found (r2=0.66; P
Databáze: OpenAIRE
Externí odkaz: