Understanding and targeting anoikis in metastasis for cancer therapies

Autor: Farzad Sattari Fard, Nazila Jalilzadeh, Amir Mehdizadeh, Fakhrosadat Sajjadian, Kobra Velaei
Rok vydání: 2022
Předmět:
Zdroj: Cell Biology International. 47:683-698
ISSN: 1095-8355
1065-6995
Popis: The development of effective treatments for cancers requires investigations for a more detailed and comprehensive understanding of the basic cellular mechanisms involved in carcinogenesis, cancer progression, and metastasis. One of those driving mechanisms is anoikis, a special type of apoptosis, which is induced by losing anchorage from the extracellular matrix (ECM). In other words, resisting death in detached cells (cells without ECM) forms an anoikis-resistant phenotype. Since the anoikis-resistance state compensates for the initial steps of cancer metastasis, this review aimed to discuss mechanisms of gaining anoikis/anoikis resistance phenotype in tumor cells. Finally, we highlighted the significance of anoikis in malignancies so as to provide clear insight into cancer diagnosis and therapy development.
Databáze: OpenAIRE
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