S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives
Autor: | Ayman B. Farag, Nahed M. Fathy, Galal H. Elgemeie, Wafaa A. Zaghary |
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Rok vydání: | 2017 |
Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy 010405 organic chemistry Chemistry Sodium Chemistry Pharmaceutical chemistry.chemical_element Glycoside Salt (chemistry) General Medicine Chemistry Techniques Synthetic Pyrazole Ethylenes 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Thioglycosides Genetics Molecular Medicine Organic chemistry Pyrazoles Glycosides |
Zdroj: | Nucleosides, nucleotidesnucleic acids. 36(3) |
ISSN: | 1532-2335 |
Popis: | A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-configuration of these cyanoethylene thioglycosides. |
Databáze: | OpenAIRE |
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